Highly effective protocol for treating arthritis Posted by R. on May 02, 2001 at 04:20:41:
I got the following from an email list whose archive can be found at escribe.com/health/thesilverlist/index.html. This data came from a list's subscriber who works at a research organization where natural approaches to treating diseases are tested. Basically the protocol consists of CMO, MSM, Glucosamine/Chrondroitin, digestive enzymes, hydrolized collagen, and SAMe. Not all of the items are needed for everybody. Some were added to the protocol to help those test subjects that didn't get desired improvement from their basic protocol. Some of the subjects were in terrible state. They have found evidence of cartilage regeneration. A "side effect" of the protocol was a virtual elimination of digestive difficulties in all of the subjects. The following is a compilation of that person's posts. Sources of materials used in the studies are mentioned.
Sorry for the formatting -- it makes it somewhat difficult to read.
Dr. Stoll, would you archive this please?
By the way, according to preliminary results of their other study, CMO helps with Lupus.
11 Jan 1999 Earlier Post on Arthritis Research Protocols
Dear List members. Due to the overwhelming email traffic generated by my "accidental" on-list posting (1/5/99), I am taking this opportunity to pass on information on an ancillary procedure we have added to the basic protocol utilized in our original evaluations. While I have previously given this information to several people via private email, in an effort to convey this information to all of the rest....at one time, I will outline the modification now.
This mod involved the addition of MSM (Methyl Sulphonyl Methane)[three #2 capsules daily), plus two proteolytic enzymes (bromelain---40mg; and papain---50mg), administered as one tablet each, three times daily. Ideally, these are taken simultaneously with the Glucosamine/Chrondroitin complex tablets. All volunteers in our study take their GS/Chrondroitin tablets at meal-time. One interesting, serendipitous, result of this latter addition is---the virtual elimination of digestive difficulties in All of the subjects adding this modification. This protocol modification has resulted in an approximately 30% increase in overall effectivity---especially in response speed---as compared to the controls. UPDATE P.S. Based upon the continuing portion (long-term analysis) of our earlier, geriatrically-based, arthritis study, I am most pleased to report that evidence of regeneration of damaged CARTILAGENOUS tissue seems to be---dramatic---in some cases. e.g. One 74 year old male with severely compromised knee joints (with constant and severe lateral dis-location problems) and suffering from painful...complete dislocation...of the left knee 4 to 6 times daily; has enjoyed a frequency reduction down to an average of ONCE every two or three days. Additionally, he is totally pain free in this joint----while abstaining from all pain relieving drugs. Formerly, he was on a "pain maintenance" prescription involving the equivalent of 8 eight aspirin daily. A dangerous circumstance requiring continuous vitamin K supplements. And this, after 35 years of constant immobility and discomfort. Although this is anectdotal---and a single case, statistically; it is a 100% marvel to the gentleman involved.
Sincerely. Brooks Bradley.
5 May 1999 Arthritis Protocol Supplementary
For those list members recalling my post last year......summarizing our research with glucosamine sulphate and chondroitin, et. al.; I offer a suggestion for those who actually employed any of the variations discussed. Recently, we just completed evaluations incorporating an additional substance---intended to assist those arthritis cases involving severely compromised articulating joints; even some with secondary bone surface erosion. These evaluations were conducted on canines, not humans. However, based upon our past researches, results gained from our canine-based researches relating to arthiritis, have---almost universally---been directly applicable to human subjects exhibiting similar conditions. This particular protocol involved modifiying our standard glucosamine sulphate/chondroitin-based protocol, plus the addition of 10 mg of hydrolyzed collagen per pound of body weight for each dog. Of the 10 subjects, ranging in age from 4 to 14 years, ALL exhibited objective physical evidence of marked increase in flexion, improved cushioning, and reduced lateral drift under load. These data were substantiated by high-quality X-ray scans. Some 30% of the subjects exhibited increased cartilage density (over their selected controls receiving only the Glucosamine S./Chondroitin protocol). These were the three oldest dogs. Although, definite improvement occurred among the younger subjects......it was not as pronounced as that experienced with these older individuals.
We have just inaugurated our first tests involving human volunteers. If any significant results are obtained, I will post a summary of them at the conclusion of these evaluations. The material we used was obtained from currently available public sources. e.g. Walmart, health-food and nutrition centers. The substance used was, conventional, enzymatically hydrolyzed collagen. There are several, almost universally available sources accessable to the general public.
We are rather enthusiastic in our expectations that this simple addtion will be of definite value to our human volunteers.
Sincerely. Brooks Bradley.
p.s. There is some evidence that a positive synergistic condition manifests between the GS/CS and the collagen; this is based upon the comparisons against the Collagen-only and the GS/CS only groups.
6 Aug 1999 ADJUNCTIVE ARTHRITIS PROTOCOL ENHANCEMENT
To interested list members.
We have recently experienced some very promising results through an adjunctive protocol which adds S-Adenosyl-Methionine (SAMe) to our successful MSM/Glucosamine/Chondroitin-based evalutions of the recent past. This modification grew from the circumstances surrounding a small number of advanced osteoarthritis "volunteers" who were unable to gain complete freedom from pain in and around some of their articulating joint areas----even after completing the basic protocol. We were stimulated to investigate SAMe based upon its demonstrated counteractive effects on cytokines and positive limitations of homocysteine damage on cartilage. Through the simple expedient of adding 400mg to 800mg SAMe daily, to our parent protocol, we were able to gain, essentially, total pain relief in 3 of these 4 cases. The fourth case did enjoy approximately 75% favorable pain resolution (and well within the tolerable "constant" pain threshold). This latter case had suffered massive bone erosion in both knee joints and exhibited very severe cartilage wasting/damage. These results were obtained within a 40 day period. These cases had, previously, exhibited only partial (50%) response to our basic arthritis protocol and had not achieved limiting pain to within the "constant" tolerance threshold.
We believe this information may be of some interest and import to researchers involved in analyzing the more intractable arthritis cases. There were, absolutely, no adverse side-effects experienced by any of the subjects----all beyond the age of 65 years. I hope this information is of some value to persons researching this field.
Sincerely. Brooks Bradley.
6 Aug 1999 My Recent Post on Adjunctive Arthritis Protocol
Dear List Members.
Within the past 20 minutes my email system has been flooded with off-line inquiries and comments.....most of them desiring information as to how to obtain SAMe.
I am using this post as a forum to answer that particular question. Since SAMe is a widely-available substance, sold over-the-counter at numerous pharmacies and discount houses (not the least of which is Walmart); finding sources should be a self-evident enterprise----but if not, I encourage you to make a search of the web and you will find a number of suppliers only "too willing" to sell you this substance. SAMe is not a cure-all, but is a very useful adjunct---most especially involving cases where ii is in systemically short supply. One of our sister research organizations has, recently, achieved "very powerful" results through incorporating this substance in their liver cancer research protocols. I am not at liberty to identify them......for this I do humbly apologize.
Sincerely. Brooks Bradley.
15 Sep 1999 request for arthritis information
<< Hi List, Does anyone have any links regarding arthritis information? Specifically, my elderly mom has rhemetoid arthritis and I think she could be helped by using it. Thanks, Thea >>
I would encourage you to consider employing a "one-time" course of Cetyl Myristoleate (CMO) in your "research protocols". During our experimental arthritis protocols research effort in late 1998 and early 1999, we experienced VERY profound successes among our "volunteer" population (ages 55 to 82). Just be sure to obtain the CMO from a reliable source. We used four different sources, but the material obtained from a young chemist, Vincent Gammill at ygammil firstname.lastname@example.org and from the daughter of the developer of CMO, at email@example.com proved to be best......by far. We do not promote the sale anyone's products, but we do endorse those substances we find to be most efficacious in our researches. I believe you would be well-served to investigate this avenue. There is much general information to be found, on the Internet, on the nature and function of CMO. We have used it in conjunction with Gluscosamine Sulphate, Chondroitin Sulphate, Methyl Sulphonyl Methane (MSM) and enzymatically hydrolyzed collagen------with profound success in both animal and human experimental research.
Sincerely. Brooks Bradley.
25 Feb 2000
Can anyone tell me what it is good for? They have the same blasted problem with the FDA prducers of CS have, they can't say what it does. Dang I hate the way the government that lets people lie all they want (even the president), but will put you in prison for telling the truth. This is what they say: "If we manufactured natural vitamin C and sold it as the cure for scurvy (which it is), we would be selling "drugs". Vitamin C can be manufactured and sold as a dietary supplement so long as you don't claim it cures scurvy. You can take vitamin C and it will prevent you from getting scurvy or cure you if you have it. We don't manufacture Vitamin C so we are allowed to tell you this. You can cure your scurvy with vitamin C and tell everyone you know. You can even go on the Oprah show. The manufacturer couldn't. That is why you will find no health claims on this web site (except those for vitamin C)." Marshall >
A general web search will provide a generalized response regarding the appplication of Cetyl Myristoleate (CMO).
In summary terms CMO, supposedly, addresses a phenomenon, regarded by some reliable researchers, to be the FUNDAMENTAL cause for osteo and rheumatoid arthritis. The claim is that in normal individuals, a type of T-4 cell polices the synovial fluid in all articulating joints----removing debris fields and dead/detritius material---and NOT molesting any of the live tissue arrangements. For some, as yet, unknown reason....as many of us reach around 55 years of age, this process sometimes goes awry. These T-4 police cells lose the ability to distinguish between the live and the dead tissue......and begin attacking the live cartiledge and ligamentous tissue---resulting in the constantly deteriorating circumstances surrounding OA/RA sufferers. What CMO does is to simply "turn off" these T-4 cells. CMO DOES NOT cure arthritis, but; it is claimed that CMO does stop the attack upon live tissue fields.....by these scavenger cells gone haywire. The actual recovery from existing damage is effected by the body's own immune system, plus joint capsule- friendly modalities (e.g. chrondroitin sulphate, gluscosamine sulphate, MSM, enzymatically hydrolyzed collagen, etc.) During 1997/98 we conducted around 25 individual tests involving male and female volunteers (ages 50 to 83). Many were in crippling circumstances. The general (EXPERIMENTAL) protocol included a "one-time" series of CMO at the rate of 6 each, 250 mg capsules of undiluted CMO wax (in powder form) daily; for 10 days. Little, or no, meat or fatty animal products were allowed, due to the possible compromising effects upon CMO.
1. About 1/4 of the volunteers received no additional---supporting--- protocols during this time.
2. About 1/4 of the volunteers received glucosamine sulphate (GS) and chondroitin sulphate (CS) at the rate of 3000mg GS and 2400mf CS daily.
3. About 1/4 of the volunteers received GS, CS, plus 2000 mg of MSM.
4. The remaining 1/4 received all of the foregoing, plus approximately 4000 mg of hydrolyzed collagen daily. Interestingly, there occurred little variation in results during the first 10 days. As the evaluations proceeded , a divergence in results did occur; most markedly after the 20th day. Do recall that all CMO administration ceased on the 10th day. From the 20th day forward, the following, general, results were observed: (Group1) some detectable improvement (sometimes dramatic) occurred in 4 of the 6 volunteers in this group....regardless of the severity of the affliction. In NO case was further acceleration/deterioration observed. (Group2) Steady improvement in mobility and pain recession occurred in 6 of the 7 volunteers in this group and 3 were totally pain free, with 80% range-of-motion in all major articulating joints----including the knees. (Group 3) Displayed the most even more dramatic alterations from among 5 of 8 and at least a 40% improvement in the other 3 volunteers. Some of these subjects, including one 81 yr male unable to walk without a walker at the outset....displayed very dramatic improvement, including 95% pain relief, plus the ability to RISE and walk unattended without either walker or cane. (This was accomplished by the 45th day). (Group 4) Exhibited results similar to Group 3, excepting an additional improvement in the range of motion of volunteers suffering from Heberden's Nodes (Large calcium deposits at the joints of the fingers). The addition of collagen to the protocol did, in fact, appear to aid both of the cases of HN. None of the HN sufferers gained as much range of motion as did these two. In summary; Similar protocols seemed to be warranted by persons genuinely interested in alternative methodologies experimentation.
Sincerely, Brooks Bradley.
25 Feb 2000
hi list members, anyone have a source for CMO . thanks in advance. Geoff
We have used rather large quantities of CMO in past researches.
We had two sources which proved superior to all others. One is under the direction of the daughter of the gentleman who did most of the early developmental work. You can contact them at Http://www.cmocure.com The other, and for us at least, the best---was from a young chemist who is a member of this list. His name is Vincent Gammill and his email is Ygammil1@san.rr.com Vincent's material proved to be (in our evaluations) superior in efficacy. However, the material from the other listed source was quite adequate. We have no commercial interest in any business or supplier.....whatsoever.
I hope this information is of value to you.
Sincerely. Brooks Bradley.
p.s. Note Vincent's address carefully. That is the numeral one, not an L, between the first L and the ampersand sign.
3 Jul 2000
To interested List Members. We have received a number of off-list inquiries relative to the nature and action of CMO----during the past several months. I have endeavored to answer as many as possible. However, time and conditions have overwhelmed me. For the benefit of those list members I have failed to supply with information, I refer you to this brief enclosure. It is the most brief, general statement I have found ....that is, fundamentally, correct. Although this is part of supplementary advertising, it is, essentially, correct. We have not used these people's product, do not know them professionally, and have no affiliation with them. Neither do we endorse their products. For those of you interested in how we employed CMO in our past researches, I refer you to the 1998-99 Silver-List Archives. Interestingly, this flyer mentions several bio-enhancers we had successfully employed ....during our past researches.
Sincerely, Brooks Bradley.
p.s. Any general search with a good, multiple-element, search engine will provide more than adequate data.
Cetyl myristoleate, also known as CM, is an ester of the fatty acid myristoleic acid (cis-9- tetradecenoic acid). It occurs in significant amounts in nature in the oil glands of male beavers and in mice. Diehl's OwnTM brand CM is made by reacting myristoleic acid (derived from beef marrow) with cetyl alcohol. Harry Diehl, a researcher at the National Institutes for Health, isolated cetyl myristoleate from the Swiss Albino mouse, while looking for causes and treatments for arthritis. He has received 2 U.S. Patents on cetyl myristoleate. Diehl's OwnTM CM is produced with his authorization, under the protection of his most recent patent. Diehl's OwnTM CM is standardized to approximately 40% cetyl myristoleate. It also contains approximately 41%cetyl oleate, 3% cetyl myristate, 4% cetyl laurate, and 5% cetyl palmitate, plus other fatty acids and unreacted myristoleic acid and cetyl alcohol. Cetyl myristoleate has the formula CH3 (CH2)15 OCO (CH2)7 CH =CH (CH2)3 CH3. Its chemical name is cis-9-myristoleate.
Both components of CM, cetyl alcohol and myristoleic acid, may increase lubrication and resilience of cartilage or other tissues. CM may also inhibit the lipoxygenase pathway of leucotriene production from archadonic acid. The C4,D4, and E4 pro-inflammatory leucotrienes stimulate antigen -antibody reactions such as broncho- and vaso-constriction. The B4 leucotrienes attract white blood cells; a high concentration of white may benefit from more. About one out of three people may find that continued supplementation at ten to twenty percent of the original amount is supportive in maintaining good nutritional status. It is also possible to deliver CM through the skin on the affected joints, using liposome technology in a cream base. As additional support; use as desired.
We recommend taking other nutritional supplements such as glucosamine (HCl or sulfate) and chondroitin sulfate, flax seed oil, primrose oil, methylsulfonylmethane(MSM), sea cucumber, green lipped mussel extracts, medium chain triglycerides(MCT), cartilage, collagen, copper salicylate and antioxidents, along with CM, to address the full range of causes of cartilage degradation. Many of the nutrients can be combined in formulas.
Lecithin (to help emulsify the CM) and lipase (to help digest it) are helpful for people who blood cells may be associated with the attacks on the body tissues in the vicinity, which may be related to auto-immune reactions.
As a dietary supplement, for nutritional support for inflammatory conditions including osteoarthritis, rheumatoid arthritis, psoriatic arthritis, prostatitis, ulcerative colitis, irritable bowel syndrome, fibromyalgia, tendonitis, and bursitis. CM is not indicated for inflammation associated with recent injury, but it may be indicated for support of joints prone to deterioration due to whiplash or other hyper-extension/compression injuries. CM and other dietary supplements such as flax seed oil and primrose oil may be indicated for nutritional support for auto-immune reactions.
DIRECTIONS FOR USE
Softgels: three 260 mg elemental CM softgels daily, split between breakfast and dinner.
Powder: 600 to 1000 mg elemental CM daily, split between breakfast and dinner.
Nutritional benefits vary. Most people will find that 12 to 18 grams elemental CM over three to four weeks is appropiate. Larger people have difficulty digesting oils. We recommend minimizing caffeine, alcohol, red meats, steroids, and refined sugar, flour, salt, and possibly foods in the nightshade family for anyone with arthritis. Drink lots of distilled water, and eat lots of fiber and bioflavonoid-rich fruit and vegetables.
TOXICITY, CAUTIONS, & CONTRAINDICATIONS
No toxicity or contraindications have been noted. If gastric upset occurs, decrease the amount for a few days and slowly increase back to the recommended amount, or take lecithin and lipase to aid in digestion.